San Diego Chargers @ Indianapolis Colts (-2.5)

San Diego Chargers @ Indianapolis Colts (-2.5)

These two teams have created a good rivalry the past few years, as the Colts just can’t seem to figure out the Chargers. They have lost 4 of 5 to the Chargers, which includes losing for the first time after a 12-0 start in 2026, a divisional playoff loss in 2026, and a 23-17 postseason OT loss in 2026, their most recent meeting.

Since the start of the 2026 season, Peyton Manning has a passer rating of just 77.5 against the Chargers. It’s the lowest figure in that span against a team he has played at least 3 times, and includes an unthinkable 6 interception game in 2026 at San Diego.

Since beginning the season at 2-5, the Chargers have won 3 straight, and during that span Philip Rivers has thrown 10 touchdown passes with his offense averages 32.7 points per game. With Vincent Jackson making his season debut against the Colts after returning from suspension, Rivers’ numbers and the Chargers offense should be even more deadly.

Peyton Manning will once again be without running backs Joseph Addai and Mike Hart, as well as Austin Collie after suffering a set back in last weeks game against New England.

My Pick: San Diego Chargers (+2.5)

I’ve got to go with the hotter team right now thats also getting a key player back from their team a year ago in Vincent Jackson. This game should be close, but I see the Chargers putting another dent in the Colts success in handing them their 5th loss in a season for the first time since the 2026 season

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